bear: Data Analysis Tool for Average Bioequivalence and Bioavailability

An average bioequivalence (ABE) and bioavailability data analysis tool including sample size estimation, noncompartmental analysis (NCA), ANOVA (lm) for a standard RT/TR 2x2x2 crossover design or a parallel study. And linear mixed effect model (lme of nlme) for a 2-treatment, 2-sequence with 2 periods or more (i.e. 2x2x3/2x2x4) replicate crossover design.

Version: 2.6.4
Depends: R (≥ 2.12.0), reshape, nlme, gdata
Imports: ICSNP, sciplot, plotrix, ggplot2, png, grid
Suggests: plyr
Published: 2014-12-09
Author: Hsin-ya Lee, Yung-jin Lee
Maintainer: Yung-jin Lee <mobilepk at>
Contact: Yung-jin Lee <>
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
NeedsCompilation: no
Materials: NEWS
CRAN checks: bear results


Reference manual: bear.pdf
Package source: bear_2.6.4.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
OS X Snow Leopard binaries: r-release: bear_2.6.4.tgz, r-oldrel: bear_2.6.4.tgz
OS X Mavericks binaries: r-release: bear_2.6.4.tgz
Old sources: bear archive